abstract：:In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexib...

journal_title：Journal of psychiatric research

authors： Steibliene V,Bunevicius A,Savickas A,Prange AJ Jr,Nemeroff CB,Bunevicius R

更新日期：2016-02-01 00:00:00

abstract：UNLABELLED:Suicide is a public health concern in older adults. Recent cross sectional studies suggest that impairments in executive functioning, memory and attention are associated with suicidal ideation in older adults. It is unknown whether these neuropsychological features predict persistent suicidal ideation. We an...

journal_title：Journal of psychiatric research

authors： Kasckow J,Youk A,Anderson SJ,Dew MA,Butters MA,Marron MM,Begley AE,Szanto K,Dombrovski AY,Mulsant BH,Lenze EJ,Reynolds CF 3rd

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Activation Syndrome (AS) is a side-effect of antidepressants consisting of irritability, mania, self-harm, akathisia, and disinhibition. The current study was conducted to analyze how AS may hinder treatment outcome for multimodal treatment for children and adolescents with Obsessive-Compulsive Disorder. MET...

journal_title：Journal of psychiatric research

authors： Reid AM,McNamara JP,Murphy TK,Guzick AG,Storch EA,Goodman WK,Geffken GR,Bussing R

更新日期：2015-12-01 00:00:00

abstract：:Neopterin, a byproduct of the tetrahydrobiopterin de novo pathway, is found in increased levels in cerebrospinal fluid and plasma and significantly increases upon damage, infection or during immune system activation. The production of this compound seems almost restricted to the monocyte/macrophage linage cells, in re...

journal_title：Journal of psychiatric research

authors： Ghisoni K,Martins Rde P,Barbeito L,Latini A

更新日期：2015-12-01 00:00:00

abstract：:A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that indiv...

journal_title：Journal of psychiatric research

authors： Moran LV,Masters GA,Pingali S,Cohen BM,Liebson E,Rajarethinam RP,Ongur D

更新日期：2015-12-01 00:00:00

abstract：:Major depressive disorder (MDD) is a severe mental illness leading to long-term disabilities. One of the current challenges in psychiatric research is to develop new approaches to investigate the pathophysiology of MDD and monitor drug response in order to provide better therapeutic strategies to the patients. Since t...

journal_title：Journal of psychiatric research

authors： Schwitzer T,Lavoie J,Giersch A,Schwan R,Laprevote V

更新日期：2015-11-01 00:00:00

abstract：:People with psychiatric disorders are excluded from medical research to an unknown degree with unknown effects. We examined the prevalence of reported psychiatric exclusion criteria using a sample of 400 highly-cited randomized trials (2002-2010) across 20 common chronic disorders (6 psychiatric and 14 other medical d...

journal_title：Journal of psychiatric research

authors： Humphreys K,Blodgett JC,Roberts LW

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This study describes the association between lifetime traumatic brain injury (TBI) and attention deficit and hyperactivity disorder (ADHD) among Canadian adults. METHOD:A cross-sectional sample of 3993 Ontario adults aged 18 or older were surveyed by Computer Assisted Telephone Interviewing (CATI) throughout...

journal_title：Journal of psychiatric research

authors： Ilie G,Vingilis ER,Mann RE,Hamilton H,Toplak M,Adlaf EM,Kolla N,Ialomiteanu A,van der Mass M,Asbridge M,Vingilis-Jaremko L,Rehm J,Cusimano MD

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and con...

journal_title：Journal of psychiatric research

authors： Hui L,Rao WW,Yu Q,Kou C,Wu JQ,He JC,Ye MJ,Liu JH,Xu XJ,Zheng K,Ruan LN,Liu HY,Hu WM,Shao TN,AngRabanes MB,Soares JC,Zhang XY

更新日期：2015-10-01 00:00:00

abstract：:Previous studies examining the association between schizophrenia and pain have produced mixed results and data on sub-threshold psychosis or psychotic symptoms and pain are scarce. This study assessed the association between psychosis and severe pain among community-dwelling adults in 44 low- and middle-income countri...

journal_title：Journal of psychiatric research

authors： Koyanagi A,Stickley A

更新日期：2015-10-01 00:00:00

abstract：:We performed an updated systematic review and meta-analysis of randomized controlled trials (RCTs) of intramuscular (IM)-olanzapine (OLA-IM) versus controls in agitated patients. The risk ratio, number-needed-to-treat/harm, and standardized mean difference based on a random effects model were calculated. We identified...

journal_title：Journal of psychiatric research

authors： Kishi T,Matsunaga S,Iwata N

更新日期：2015-09-01 00:00:00

abstract：:Suicide rates among U.S. military personnel and veterans are a public health concern, and those with mental health conditions are at particular risk. We examined demographic, military, temporal, and diagnostic associations with suicidality in veterans. We conducted a population-based, retrospective cohort study of all...

journal_title：Journal of psychiatric research

authors： Maguen S,Madden E,Cohen BE,Bertenthal D,Neylan TC,Seal KH

更新日期：2015-09-01 00:00:00

abstract：:The etiology of schizophrenia continues to be confounding and elusive. Some knowledge gaps exist in the neurodegenerative theory of schizophrenia. Oxidative DNA damage and repair deficits are relevant to the mechanisms of neurodegeneration but have not been studied in drug naïve schizophrenia. The present study used t...

journal_title：Journal of psychiatric research

authors： Muraleedharan A,Menon V,Rajkumar RP,Chand P

更新日期：2015-09-01 00:00:00

abstract：:Various studies have assessed autonomic and respiratory underpinnings of panic attacks, yet the psychophysiological functioning of panic disorder (PD) patients has rarely been examined under naturalistic conditions at times when acute attacks were not reported. We hypothesized that emotional activation in daily life c...

journal_title：Journal of psychiatric research

authors： Pfaltz MC,Kolodyazhniy V,Blechert J,Margraf J,Grossman P,Wilhelm FH

更新日期：2015-09-01 00:00:00

abstract：:The Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) formally introduced a dissociative subtype of posttraumatic stress disorder (PTSD). This study examined the proportion of U.S. veterans with DSM-5 PTSD that report dissociative symptoms; and compared veterans with PTSD with and without the ...

journal_title：Journal of psychiatric research

authors： Tsai J,Armour C,Southwick SM,Pietrzak RH

更新日期：2015-07-01 00:00:00

abstract：:People with psychotic disorders, including schizophrenia (SCZ), schizoaffective disorder (SD), or other non-affective psychoses (ONAP), have a higher risk of metabolic syndrome (MetS) than general population. However, previous meta-analyses failed to explore if people with SD are more likely to suffer from MetS than S...

journal_title：Journal of psychiatric research

authors： Bartoli F,Crocamo C,Caslini M,Clerici M,Carrà G

更新日期：2015-07-01 00:00:00

abstract：:A fraction of genetic risk to develop schizophrenia may be due to low-frequency variants. This multistep study attempted to find low-frequency variants of high effect at coding regions of eleven schizophrenia susceptibility genes supported by genome-wide association studies (GWAS) and nine genes for the DISC1 interact...

journal_title：Journal of psychiatric research

authors： Suárez-Rama JJ,Arrojo M,Sobrino B,Amigo J,Brenlla J,Agra S,Paz E,Brión M,Carracedo Á,Páramo M,Costas J

更新日期：2015-07-01 00:00:00

abstract：:In the last couple of years, non-coding (nc) RNAs like micro-RNAs (miRNAs), small interference RNAs (siRNAs) and long ncRNAs (lncRNAs) have emerged as promising candidates for biomarkers and drug-targets in a variety of psychiatric disorders. In contrast to reports on ncRNAs in affective disorders, schizophrenia and a...

journal_title：Journal of psychiatric research

authors： Schmidt U,Keck ME,Buell DR

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Earlier age at onset of psychosis (AOP) has been associated with poor social adjustment and clinical outcome. Genetic and environmental factors such as obstetric complications, parental history of psychosis, advanced paternal age at time of birth, low birth weight and gestational age, and use of drugs have b...

journal_title：Journal of psychiatric research

authors： Rubio-Abadal E,Ochoa S,Barajas A,Baños I,Dolz M,Sanchez B,Del Cacho N,Carlson J,Huerta-Ramos E,GENIPE Group.,Usall J

更新日期：2015-06-01 00:00:00

abstract：:Although self-harm has been observed among patients with eating disorders, the effects of such tendencies on treatment outcomes are unclear. The current study employed structural equation modeling to (a) evaluate the relationship between self-harm and changes in body dissatisfaction and drive for thinness in a large s...

journal_title：Journal of psychiatric research

authors： Olatunji BO,Cox R,Ebesutani C,Wall D

更新日期：2015-06-01 00:00:00

abstract：:The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression lev...

journal_title：Journal of psychiatric research

authors： Bassi S,Seney ML,Argibay P,Sibille E

更新日期：2015-04-01 00:00:00

abstract：:Bipolar Disorder (BD) is one of the most severe psychiatric disorders. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on manic-like behaviors. Neurotrophins have...

journal_title：Journal of psychiatric research

authors： Varela RB,Valvassori SS,Lopes-Borges J,Mariot E,Dal-Pont GC,Amboni RT,Bianchini G,Quevedo J

更新日期：2015-02-01 00:00:00

abstract：:Our aim was to create a clinically useful risk index, administered prior to discharge, for determining the probability of psychiatric readmission within 30 days of hospital discharge for general psychiatric inpatients. We used population-level sociodemographic and health administrative data to develop a predictive mod...

journal_title：Journal of psychiatric research

authors： Vigod SN,Kurdyak PA,Seitz D,Herrmann N,Fung K,Lin E,Perlman C,Taylor VH,Rochon PA,Gruneir A

更新日期：2015-02-01 00:00:00

abstract：:We have previously demonstrated an impairment of intraplatelet L-arginine-nitric oxide-cGMP pathway in major depression (MD) associated to platelet dysfunction. Here, we evaluated arginase pathway and phosphodiesterase 5 (PDE5) expression in platelets, systemic and intraplatelet oxidative status in untreated MD patien...

journal_title：Journal of psychiatric research

authors： Ormonde do Carmo MB,Mendes-Ribeiro AC,Matsuura C,Pinto VL,Mury WV,Pinto NO,Moss MB,Ferraz MR,Brunini TM

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for ...

journal_title：Journal of psychiatric research

authors： Peñas-Lledó E,Guillaume S,Delgado A,Naranjo ME,Jaussent I,LLerena A,Courtet P

更新日期：2015-02-01 00:00:00

abstract：:Self-harm behaviors are a major public health concern across the lifespan, particularly among individuals with psychiatric disorders. Little research, however, has examined these behaviors among individuals with a diagnosis characterized by recurrent acts of impulsive aggression, Intermittent Explosive Disorder (IED)....

journal_title：Journal of psychiatric research

authors： Jenkins AL,McCloskey MS,Kulper D,Berman ME,Coccaro EF

更新日期：2015-01-01 00:00:00

abstract：:Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF l...

journal_title：Journal of psychiatric research

authors： Szuhany KL,Bugatti M,Otto MW

更新日期：2015-01-01 00:00:00

abstract：:Improved utilization of continuous or intermittent opioid administration in pain treatment necessitates a comparison of the antinociceptive effect and tolerance of these two treatment methods. More importantly, the effect of treatment method on subsequent opioid consumption has not been directly compared, although it ...

journal_title：Journal of psychiatric research

authors： Yu G,Zhang FQ,Tang SE,Lai MJ,Su RB,Gong ZH

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Preclinical and clinical studies support a role for brain-derived neurotrophic factor (BDNF) in the pathophysiology of stress-related mood disorders. Furthermore, BDNF seems to be linked to antidepressant action. Available pharmacological treatments for depression are characterized by significant limitations ...

journal_title：Journal of psychiatric research

authors： Giese M,Beck J,Brand S,Muheim F,Hemmeter U,Hatzinger M,Holsboer-Trachsler E,Eckert A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:This nationwide population-based study investigated the risk of Parkinson's disease (PD) after zolpidem use in patients with sleep disturbance using the National Health Insurance Research Database (NHIRD) in Taiwan. MATERIAL AND METHODS:In total, 59,548 adult patients newly diagnosed with sleep disturbance ...

journal_title：Journal of psychiatric research

authors： Yang YW,Hsieh TF,Yu CH,Huang YS,Lee CC,Tsai TH

更新日期：2014-11-01 00:00:00

abstract：:Although it is largely demonstrated that Autism Spectrum Disorders (ASDs) are characterized by executive dysfunctions, little is known about the fine-grained levels of this impairment. Here, we investigated the hierarchical architecture of control modules in autism using an experimental paradigm based upon a multistag...

journal_title：Journal of psychiatric research

authors： Barbalat G,Leboyer M,Zalla T

更新日期：2014-11-01 00:00:00

abstract：:The hypothalamus-pituitary-adrenal axis (HPA) is essential in the regulation of stress responses. Increased methylation of the promoter region of the glucocorticoid receptor gene (NR3C1) has been described both in subjects with history of childhood trauma and in patients with Borderline Personality Disorder (BPD). How...

journal_title：Journal of psychiatric research

authors： Martín-Blanco A,Ferrer M,Soler J,Salazar J,Vega D,Andión O,Sanchez-Mora C,Arranz MJ,Ribases M,Feliu-Soler A,Pérez V,Pascual JC

更新日期：2014-10-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementati...

journal_title：Journal of psychiatric research

authors： Evans SJ,Ringrose RN,Harrington GJ,Mancuso P,Burant CF,McInnis MG

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Sleep complaints have been linked with Obsessive Compulsive Disorder (OCD), though there is a dearth of research exploring the association between a range of disturbed sleep indicators and obsessive compulsive symptoms (OCS). Two separate studies were conducted to rigorously investigate this relationship in ...

journal_title：Journal of psychiatric research

authors： Timpano KR,Carbonella JY,Bernert RA,Schmidt NB

更新日期：2014-10-01 00:00:00

abstract：:The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we have used cyclin D2 knockout mice (cD2 KO mice), ...

journal_title：Journal of psychiatric research

authors： Jedynak P,Kos T,Sandi C,Kaczmarek L,Filipkowski RK

更新日期：2014-09-01 00:00:00

abstract：:Despite the fact that the majority of currently available treatment guidelines propose antidepressants as the first-line pharmacological therapy for posttraumatic stress disorder (PTSD), a substantial portion of patients fail to show an adequate response following this type of treatment. In this context, a number of s...

journal_title：Journal of psychiatric research

authors： Han C,Pae CU,Wang SM,Lee SJ,Patkar AA,Masand PS,Serretti A

更新日期：2014-09-01 00:00:00

abstract：:Urban vs. rural residence is commonly cited as a risk factor for depression and other mental disorders, but epidemiological evidence for this relationship in the US is inconclusive. We examined three consecutive annual samples (2009-2011) of adolescents (age 12-17, N = 55,583) and adults (age 18 and over, N = 116,459)...

journal_title：Journal of psychiatric research

authors： Breslau J,Marshall GN,Pincus HA,Brown RA

更新日期：2014-09-01 00:00:00

abstract：:Intermittent Explosive Disorder (IED) is a relatively common disorder of impulsive aggression that typically emerges by adulthood. Maltreatment in childhood (CM) may contribute to the development of IED, but little is known about the association between CM and IED, including about how subtypes of CM may specifically r...

journal_title：Journal of psychiatric research

authors： Fanning JR,Meyerhoff JJ,Lee R,Coccaro EF

更新日期：2014-09-01 00:00:00

abstract：:Chronic schizophrenia patients have personality abnormalities and cognitive deficits that are associated with poor clinical, social, and vocational outcomes. Very few studies have examined relationships between personality and cognitive function, and chronic illness effects may have confounded those studies. In this s...

journal_title：Journal of psychiatric research

authors： Gurrera RJ,McCarley RW,Salisbury D

更新日期：2014-08-01 00:00:00

abstract：:There are strong links between childhood trauma and the risk of violence (Ford et al., 2007). Despite evidence that people with psychotic disorders are at a higher risk of violence than the general population (Witt et al., 2013) there have been few studies that have examined the trauma-violence link in this population...

journal_title：Journal of psychiatric research

authors： Bosqui TJ,Shannon C,Tiernan B,Beattie N,Ferguson J,Mulholland C

更新日期：2014-07-01 00:00:00